A Vaccine Is Suppressing Peanut Allergy Symptoms In Mice

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Latest News : A vaccine is suppressing peanut allergy symptoms in mice

Peanut allergy symptoms in mice have been successfully turned off by a vaccine — and researchers hope related remedy might sooner or later be out there for people.

A nasal spray, created by researchers on the College of Michigan and administered in three month-to-month doses, proved to protect the small animals from any unfavourable responses to peanuts. The researchers have labored for nearly 20 years to get the drug thus far — successfully refocusing the immune cells on what the physique is allergic to, stopping a response.

“We’re altering the way in which the immune cells reply upon publicity to allergens,” lead creator of the examine Jessica O’Konek informed the UM well being weblog, M Well being Lab. “Importantly, we will do that after allergy is established, which supplies for potential remedy of allergy symptoms in people.

“By redirecting the immune responses, our vaccine not solely suppresses the response however prevents the activation of cells that will provoke allergic reactions,” she mentioned.

Within the examine, revealed within the Journal of Allergy and Scientific Immunology, the researchers mentioned that earlier than the vaccine, the allergic mice skilled a few of the identical signs after ingesting peanuts as people, like itchy pores and skin and issue respiration. However two weeks after doses of the vaccine had been administered, the mice started experiencing “safety” from their typical allergic responses.

The examine is at present targeted on determining how lengthy the mice are protected against the allergy however the crew expects the outcomes to be long-lasting.

“Proper now, the one FDA-approved method to tackle meals allergy is to keep away from the meals or suppress allergic reactions after they’ve already began,” O’Konek mentioned. “Our purpose is to make use of immunotherapy to alter the immune system’s response by growing a therapeutic vaccine for meals allergy symptoms.”

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